In 2012, the Global Commission on HIV and the Law called on countries to outlaw discrimination, repeal punitive laws and enact protective laws to promote public health and human rights for effective HIV responses. Today, more than 89 countries have taken action to repeal or reform laws.

This Supplement highlights developments since 2012 in science, technology, law, geopolitics, and funding that affect people living with or at risk from HIV and its co-infections. The recommendations add to and amplify those of the Commission’s 2012 report Risks, Rights & Health, which remain as relevant as they were six years ago.